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Old 11-11-2012
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ObGyn separating AFLP from severe preclampsia

what will be clues in q separating one from another ?

if u say, hyperammonia, hypo glucose, encephalopathy in AFLP...they may be present in severe preclampsia... so as of now, i think we cannot make any difference and treatment for both is same...deliver!
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Old 11-11-2012
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AFLP has renal failure and most importantly abnormal coagulation studies. These help to distinguish it from preeclampsia or HELLP.
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Quote:
Originally Posted by Triquetrum View Post
AFLP has renal failure and most importantly abnormal coagulation studies. These help to distinguish it from preeclampsia or HELLP.
yup, just the microangiopathic part may differ...thanks
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Old 11-11-2012
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Anything is possible in any condition-Death being the common denominator!
However, for USMLE purpose they have to stick to some differentiating features.
The features which differentiate AFLP from HELLP syndrome & PreEclampsia are raised serum Ammonia & Hypoglycemia.
Another feature of AFLP is microvesicular fat deposition in hepatocytes without evidence of inflammation or necrosis.

Remember the Conrad Fischer Mantra " They have to give you something (clues) if they want to know the answer".
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Old 11-20-2012
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Crudely can say:
AFLP= HELLP syndrome + increase serum Ammonia + Hypoglycemia + renal failure + coagulopathy
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Another way to remember is that AFLP presentation is similar to Reye's syndrome including the histopathological findings of microvesicular fat deposition in hepatocytes without evidence of inflammation or necrosis.
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