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  #1  
Old 01-16-2013
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Default Nurodoc q1

A 45-year-old man comes to the emergency department because of headache and discharge from his left ear for 2 days. Two days ago, he suffered a head injury in a motor vehicle accident. His medical history is unremarkable. He is in no distress. His temperature is 36.7 deg C, blood pressure is 128/64 mm Hg, pulse is 82/min, and respirations are 16/min. Examinations shows a clear, watery discharge from the left ear. The remainder of the examination shows no abnormalities. Which of the following is the most appropriate diagnostic rest for this patient's ear discharge?

a) beta-2-transferrin
b) glucose level
c) protein analysis
d) salt content
e) specific gravity
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  #2  
Old 01-16-2013
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beta-2-transferrin.........otorrhea

Beta-2 transferrin is a carbohydrate-free (desialated) isoform of transferrin, which is almost exclusively found in the cerebrospinal fluid. It is not found in blood, mucus or tears, thus making it a specific marker of cerebrospinal fluid, applied as an assay in cases where cerebrospinal fluid leakage is suspected.[1]
Beta-2 transferrin would also be positive in patients with perilymph fluid leaks, as it is also present in inner ear perilymph. Thus, beta-2 transferrin in otorrhea would be suggestive of either a CSF leak or a perilymph leak.[2]
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anomali (01-16-2013), doxorubicin (01-16-2013), sohailus (01-16-2013)
  #3  
Old 01-17-2013
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Quote:
Originally Posted by aknz View Post
beta-2-transferrin.........otorrhea

Beta-2 transferrin is a carbohydrate-free (desialated) isoform of transferrin, which is almost exclusively found in the cerebrospinal fluid. It is not found in blood, mucus or tears, thus making it a specific marker of cerebrospinal fluid, applied as an assay in cases where cerebrospinal fluid leakage is suspected.[1]
Beta-2 transferrin would also be positive in patients with perilymph fluid leaks, as it is also present in inner ear perilymph. Thus, beta-2 transferrin in otorrhea would be suggestive of either a CSF leak or a perilymph leak.[2]

-yes ur right,but the result might takes dayes to weeks.so what?!
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  #4  
Old 01-17-2013
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Default a) beta-2-transferrin

a) beta-2-transferrin
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