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  #1  
Old 02-28-2013
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Question nephro q

a 36 year male presents with history of fatigue+Anasarca.he was recently diagnosed with hodgkins lymphoma.all his lab tests are normal except for decreased albumin.urinalysis revealed 4+ proteinuria.renal biopsy most likely reveals
a)membranous GN
b)minimal change
c)cresenteric GN
D)MPGN
E)Diffuse proliferative GN
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  #2  
Old 02-28-2013
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Originally Posted by rupesh View Post
a 36 year male presents with history of fatigue+Anasarca.he was recently diagnosed with hodgkins lymphoma.all his lab tests are normal except for decreased albumin.urinalysis revealed 4+ proteinuria.renal biopsy most likely reveals

a)membranous GN

b)minimal change
c)cresenteric GN
D)MPGN
E)Diffuse proliferative GN
Most common cause of nephrotic syndrome in adults Diffuse membranous nephropathy............Here buzzword is Malignancy: Hodgkin Lymphoma
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  #3  
Old 02-28-2013
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b)minimal change
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Old 02-28-2013
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b) minimal change

thanks
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Old 02-28-2013
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Originally Posted by rupesh View Post
a 36 year male presents with history of fatigue+Anasarca.he was recently diagnosed with hodgkins lymphoma.all his lab tests are normal except for decreased albumin.urinalysis revealed 4+ proteinuria.renal biopsy most likely reveals
a)membranous GN
b)minimal change
c)cresenteric GN
D)MPGN
E)Diffuse proliferative GN
B. minimal change dz
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Old 02-28-2013
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Originally Posted by Novobiocin View Post
b)minimal change

Explanation please ..........As Hodgkin's lymphoma is a secondary cause of nephrotic syndrome of both case of MCD as well as Membranous glomerulopathy. But here pt. is an adult whereas about 15% of cases of MCD is associated with adult but most common cause of nephrotic syndrome in adult is Membranous glomerulopathy.
So wht's the key word here that lead to MCD???
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Old 02-28-2013
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Explanation please ..........As Hodgkin's lymphoma is a secondary cause of nephrotic syndrome of both case of MCD as well as Membranous glomerulopathy. But here pt. is an adult whereas about 15% of cases of MCD is associated with adult but most common cause of nephrotic syndrome in adult is Membranous glomerulopathy.
So wht's the key word here that lead to MCD???
Ya u are right,
I also remember from rapid review that Hodgkin lymphoma or any carcinoma is associated with membranous GN but while doing UW question I came across this question with states that Hodgkin causes minimal change dz. Patho physiology is not properly understood but lymphocyte production and cytokines play a role.
So I concluded
Any carcinoma + GN - membranous
Hodgkin + GN- minimal change
Hope it helps
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  #8  
Old 03-01-2013
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Originally Posted by koolkiller88 View Post
Ya u are right,
I also remember from rapid review that Hodgkin lymphoma or any carcinoma is associated with membranous GN but while doing UW question I came across this question with states that Hodgkin causes minimal change dz. Patho physiology is not properly understood but lymphocyte production and cytokines play a role.
So I concluded
Any carcinoma + GN - membranous
Hodgkin + GN- minimal change
Hope it helps

Yeah........but Goljan states Hodgkin lymphoma as both cause of MCD & Membranous glomerulopathy. How do u conclude this from the question stem only MCD???
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Old 03-01-2013
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Correct Answer b

i did this question yesterday and i too choose membranous nephropathy .......but as per uworld facts all cancer results in membranous nephropathy except hodgkins which results in lipoid nephrosis.....
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  #10  
Old 03-01-2013
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Originally Posted by Master shifu View Post
Explanation please ..........

So wht's the key word here that lead to MCD???
All solid tumors are associated with Membranous glomerulopathy and Hematological malignancies are associated with Minimal change Disease.
It's given in FA Step 2 (Table) also.
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