Muscle cramps in hypothyroidism? - USMLE Forums
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Old 09-24-2010
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Thyroid Muscle cramps in hypothyroidism?

What is the mechanism of muscle cramps in this condition?
I can't find any information about this.
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Old 09-25-2010
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The parathyroid hormone functions to increase the level of plasma calcium by several mechanisms.

If a patient is hypoparathyroid, it means that his/her plasma level of thyroid hormone is low. A low hypothryroid hormone means low plasma level of of calcium and this is the low plasma level of calcium that increases the excitability of peripheral nerves ( including motor nerves that supply the muscle ) and subsequently increased frequency of stimulatory signals to muscle......and eventually results in muscle cramps.
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Old 09-25-2010
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Thank you Dr. Elham for your explanation.
but my question was about hypothyrodism not parahypothyrodism.
What exactly causes the muscle cramps in thyroid hormone deficit?
What kind of electrolite disturbance causes it?
Is this due to low Ca++ or low Na+?
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Old 09-25-2010
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have a look at this site...
it will help u....

http://emedicine.medscape.com/article/313915-overview
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donofitaly (09-26-2010), Ethar (09-26-2010)
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Old 09-26-2010
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Default That's not HY

Quote:
Originally Posted by Pav100 View Post
What is the mechanism of muscle cramps in this condition?
I can't find any information about this.
Was there a question asking you how?
I don't think we should go into that details for the exam.
It's nice to know it but you won't be asked about it in the exam, I think ...

Anyways, hyponatremia causes membrane instability and maybe the result of the muscle cramps.
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Old 09-27-2010
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Thank you Khushboo !
Now it's clear for me.

To Ethar
Yeah, you right. The main cause of muscle cramps in hypothyr. is low Na+

I am asking about these concepts in order to clearly understand. Once you get it, you gonna remember it for all of your life and also you gonna better understand what's is exactly going on in a particular disease.
I am just following the Goljan advice.
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