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Old 03-05-2013
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Default to confirm AIP

A 22 year old woman is evaluated in the office for recurrent attacks of colicky abdominal pain that resolve spontaneously. During the episodes, the pain lasts about 8 to 10 hours and resolves spontaneously. Several clinical examinations, laboratory investigations and imaging studies in the past have failed to reveal any clear etiology. She also reports recurrent swelling of her hands and feet, the last episode being 2 weeks ago. Physical examination is benign. A complete blood count and comprehensive metabolic panel are with in normal limits. Which of the following is most helpful in confirming the suspected diagnosis?

a) Urinary Porphobilinogen

b) Radio Allergosorbent Test ( RAST)

c) Anti-nuclear antibodies

d) C1-Inhibitor

e) 24 hour delta-aminolevulinic acid
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radkur (03-07-2013)

Old 03-06-2013
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Default a) Urinary Porphobilinogen

a) Urinary Porphobilinogen
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stfidel (03-06-2013)
Old 03-06-2013
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Urine from a person experiencing an acute attack may be red or "port wine" in color because of the presence of porphyrins. In addition, urine of AIP sufferers may turn purple when exposed to ultraviolet light for a period of time.

Barbiturates and Primidone must be avoided as they commonly precipitate symptoms
A man doesn't know what he knows until he knows what he doesn't know.
“What is man? He's just a collection of chemicals with delusions of grandeur.”
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Old 03-07-2013
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A this one was a very good question and tough one. I could get an idea of what type of case this was after reading the options. The patient in this case presents symptoms that can be found in all other cases. She is young and OFTEN presents pain and SWELLING of the hands and feet. Still was not that clear for me but the pain resolving on its own descarded the other options.

AIP is an autosomal dominant and presents in teen years and with more symptos in women. Changes in salt and water balance may contribute to the presentation of some of the symptoms.

Good question! Hard one!
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Old 03-07-2013
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I had no clue what this one was ...
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