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Old 03-05-2013
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Default cause of hypokalemia with Low LAP score

A 55 year old man comes to the Emergency Room complaining of left upper quadrant discomfort. His physical examination reveals Splenomegaly. Laboratory investigations were sent but there was a significant delay in sending the specimen to the laboratory after collection. Laboratory investigations reveal a WBC count of 110,000/µl with neutrophilia, basophilia and eosinophilia and Serum potassium of 3.0/µl. Leucocyte Alkaline Phosphatase level is low. A bone marrow biopsy is obtained and the results are pending. The most likely explanation of the patients hypokalemia :

A) Delay in specimen transport to lab

B) Marked Leucocytosis and Delay in specimen transport

C) Tumor Lysis

D) Splenomegaly

E) Renal loss
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Old 03-05-2013
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Default Hmmm

check this link

http://www.ncbi.nlm.nih.gov/pubmed/6940517
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Old 03-06-2013
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E) Renal loss
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Old 03-06-2013
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Quote:
Originally Posted by dralan View Post
E) Renal loss
absolutely right...hyperkaluresis occurs in the setting of lysozymuria due to huge WBC count and results in renal loss
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Old 03-06-2013
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Quote:
Originally Posted by stfidel View Post
.hyperkaluresis occurs in the setting of lysozymuria due to huge WBC count and results in renal loss
Explain the pathophysiology please
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