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Old 05-12-2013
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Question Vitamin A and the Parathyroid Function

guys,

i've a doubt....how hypo/hyper parathroidism is associated with vit.A def./toxicity...?
(couldnt find it in google)

given in mtb2 ck---2012 edition pg. 438

pls anyone clarify me....thanks

Last edited by venky2600; 05-12-2013 at 04:41 AM. Reason: change of question
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Old 05-12-2013
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Vitamin A toxicity causes hypercalcemia especially in pediatric population, this hypercalcemia may leads to the suppression of PTH,, but I am not sure there is direct relationship of PTH exists or not.
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Quote:
Originally Posted by salman View Post
Vitamin A toxicity causes hypercalcemia especially in pediatric population, this hypercalcemia may leads to the suppression of PTH,, but I am not sure there is direct relationship of PTH exists or not.
thank you salman...but what's the pathophysiology of causing hypercalcemia due to Vit.A toxicity....

but in mtb --they gave vit.A toxicity causes hyperparathyroid (not PTH suppression)

am i missing anything here..?
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Old 05-12-2013
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No, venky I read from pubmed that vit A toxicity causes hypercalcemia and they told that mechanism is not clear may be due to osteoclasts activation, but it's an old article about 1990s so I am also not sure, but will you please tell me in mtb2 ck where they wrote that it causes hyperparathyriodism because I also ve 2012. Edition but on page 438 there r some musculoskeletal diseases, I mean the topic, thanks in advance
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Quote:
Originally Posted by salman View Post
No,venky I read from pubmed that vit A toxicity causes hypercalcemia and they told that mechanism is not clear may be due to osteoclasts activation,but it's an old article about 1990,s so I am also not sure ,but will you please tell me in mtb2 ck where they wrote that it causes hyperparathyriodism because I also ve 2012. Edition but on page 438 there r some musculoskeletal diseases,I mean the topic ,thanks in advance
ok buddy

i already posted earlier...that in pg. 438 pediatrics last page ---vitamin deficiencies and toxicities(table)
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