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Old 10-30-2010
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Star Methylene Blue in Clinical Medicine?

do u know the medical usage of methylene blue in medicine ... especially in cancer ... and what are its side effects ... please with references ...
thank u

Hosam
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Old 10-30-2010
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I was just reading on Hemoglobin, and methylene blue is used to treat methemoglobinemia as well as the enzyme methhemoglobin reductase will yield this reaction, it reduces ferric iron (Fe3+ bec. methemoglobin is useless in itself at the ferric form) to ferrous iron (Fe2+) or normal hgb and using the NADH as a reductant.

Genetic deficiency of methhemoglobin reductace have congenital methemoglobinemia.

I hope that helps.
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Old 10-31-2010
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reduced iron binds oxygen better rite? thats y we need to reduce it?
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Old 10-31-2010
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Seetal,

HEME iron in Hgb and myoblobin is ALWAYS in the ferrous (Fe2+) state. BioMolecular structure is similar.
Even during Oxygen Binding, it is not oxidized to ferric (Fe3+) form.

It become OXYGENATED but NOT oxidized.

If you recall, HEME is Hgb, is the Oxygen Binding prosthetic group; heme group consist of porphyrin PROTOPORPHYRIN IX with a FERROUS IRON chelated in its center.

That's why it is ALWAYS in the ferrous state.

Last edited by md_nxt_dr; 10-31-2010 at 12:47 PM. Reason: added info
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Old 10-31-2010
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Seetal,

So, to answer your question---No, it has nothing to do with Oxygen Binding because even during Oxygen Binding, Fe2+ it is not oxidized.

Iron in heme group can exist in Ferrous (Fe2+) and Ferric (Fe3+) state except FERRIC form is useless hgb or METHEMOGLOBIN.

Methgb is treated with methgb reductase to covert it to normal hgb using NADPH as reductant.

Methylene blue is used to treat congenital methemoglobinemia bec. of complete absence of methgb reductase.

Remember; ferrous--ous---"o"--two-- Fe2+ (reduced form) normal hgb

ferric---ic--"i"-third--Fe3+ (oxidized form) useless hgb

hope that helps clarify things

Last edited by md_nxt_dr; 10-31-2010 at 02:24 PM. Reason: added
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Old 11-01-2010
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Default hmm ok. thx guys.

but i checked in goljan path secret notes again, he says that MetHb causes O2 saturation to decrease because the Hb is Fe3+ not Fe2+. then in his audio he says that O2 binds to Fe2+ not Fe3+ so oxygen saturation decreases in MetHb. n to reverse this or to aid in conversion of Fe3 to Fe2, we can use methylene blue and also vit C (but is not main treatment).

thx for the nmenonic. FerrOus-O2 (Fe2+), FerrIc (Fe3+)...
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