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Old 07-30-2013
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Default Q: What is the mechanism of this guy's angioedema?

Q: A guy is cleaning his garage, gets stung by a bee. develops the symptoms of angioedema. What is the cause of his angioedema.

A) Increased bradykinin levels
B) Increased Complement levels
C) Increased degranulation of mast cells
D) Increased circulating antibodies
E) Increased foreign bodies
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Mast cell degranulation
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Originally Posted by DocSikorski View Post
Mast cell degranulation
you sure? don;t you need to be sensitized first for a type 1 hypersensitivity? this dude had a one time sting by a bee, his mast cells haven't been sensitized with IgE yet in order to allow for degranulation next time he is exposed to that allergen again.
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Originally Posted by Dr.NickRiviera View Post
you sure? don;t you need to be sensitized first for a type 1 hypersensitivity? this dude had a one time sting by a bee, his mast cells haven't been sensitized with IgE yet in order to allow for degranulation next time he is exposed to that allergen again.
Ugh...
If its a first time bee sting (and we are talking that he is allergic to it down the road) so he will not experience anything

Its like with penicillin - give it first time - all is fine, but on the second time - people explode and their face melts off...
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Ugh...
If its a first time bee sting (and we are talking that he is allergic to it down the road) so he will not experience anything

Its like with penicillin - give it first time - all is fine, but on the second time - people explode and their face melts off...

yea, so doesn't he have to be sensitized to it before hand for it to be a type I hypersensitivity?

and its angioedema, not like an anaphylactic rxn. isnt angioedema only 1 of 2 mechanisms; either C1-inh deficiency (what i think it is here), or ACE-I use?
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I assume this angioedema after a bee sting is an anaphylaxys -so mast cell degranulation than
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Originally Posted by DocSikorski View Post
I assume this angioedema after a bee sting is an anaphylaxys -so mast cell degranulation than
but by definition, isnt an anaphylactic rxn one of exposure to an allergen which you've been sensitized to? maybe im thinking into it too much and its an easy question. but i feel like, not everyone who gets stung by a bee gets angioedema. he must have some genetic buggery going on. so maybe a c1-inh deficiency. because for it to be a type I hypersensitivity, he would have had to be stung by a bee before, no rxn, and now on second bee sting, he gets angioedema. although question doesnt mention anything about previous exposure to bee stings, wouldn't they have to mention it to tell you, hey hes been sensitized, and now hes got this on second exposure.
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Originally Posted by Dr.NickRiviera View Post
but by definition, isnt an anaphylactic rxn one of exposure to an allergen which you've been sensitized to? maybe im thinking into it too much and its an easy question. but i feel like, not everyone who gets stung by a bee gets angioedema. he must have some genetic buggery going on. so maybe a c1-inh deficiency. because for it to be a type I hypersensitivity, he would have had to be stung by a bee before, no rxn, and now on second bee sting, he gets angioedema. although question doesnt mention anything about previous exposure to bee stings, wouldn't they have to mention it to tell you, hey hes been sensitized, and now hes got this on second exposure.
Ugh, I dunno,
Maybe he was stung - maybe he wasn't - they do not have to tell you that, since its so common...
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Ugh, I dunno,
Maybe he was stung - maybe he wasn't - they do not have to tell you that, since its so common...
hmmmmmm true
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Quote:
Originally Posted by Dr.NickRiviera View Post
Q: A guy is cleaning his garage, gets stung by a bee. develops the symptoms of angioedema. What is the cause of his angioedema.

A) Increased bradykinin levels
B) Increased Complement levels
C) Increased degranulation of mast cells
D) Increased circulating antibodies
E) Increased foreign bodies
If there is no history of previous bee stings then A is the answer.
If the has had 1 bee sting before then C is the answer
If there is Angioedema without Urticaria then A is the answer.
If there is Angioedema WITH urticaria then C is the answer..

Depends on what they give you

Source: http://emedicine.medscape.com/articl...ew#aw2aab6b2b2
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