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Old 08-14-2013
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Question Hepatorenal syndrome

Can somebody explain this plz.
In severe liver dis. there is generalized secondary systemic vasodilation
so dec. PVR
so how does that lead to renal hypoperfusion??
i guess some renal physio i have forgotten.
anyway uw goes like- dec. PVR so renal hypoperfusion
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Old 08-14-2013
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ok so i found this topic has been discussed in some old threads
in oversimplified terms
Systemic VD---> peripheral pooling ---> renal hypoperfusion
--->RAS activ ---> VC of aff arteriole
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Old 08-14-2013
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Quote:
Originally Posted by rg99 View Post
Can somebody explain this plz.
In severe liver dis. there is generalized secondary systemic vasodilation
so dec. PVR
so how does that lead to renal hypoperfusion??
i guess some renal physio i have forgotten.
anyway uw goes like- dec. PVR so renal hypoperfusion
Think of it as the same pathophys of anaphylactic shock (systemic vasodilation leads to decreased perfusion to all organs

so a systemic dilation in hepatorenal will lead to decreased perfusion to renal
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Old 10-06-2013
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Info Hypotension

you need tone in blood vessels for appropriate circulation of blood
VD---> pooling and stasis---->no proper perfusion ( same way in CHF, sepsis, anaphylaxis where heart pumping is defective resulting decreased renal perfusion )

the VC is the body mechanism to try to compensate for hypotension
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