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Old 09-24-2013
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Question what is the best initial therapy for severe parkinsonism?

best initial therapy for severe parkinsonism??? KLN notes and video lectures say levodopa/carbidopa, while MTB 2 says pramipexole or ropinrole?
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Old 05-04-2014
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Tenee my notes say


DOC
1st Line --> Levodopa + Carbidopa

2nd Line --> Non-ergot dopamine agonists
  • Pramipexole
  • Ropinirole
  • Rotigotine
  • Apomorphine

2nd line Non-ergot dopamine agonists are now-a-days being used for initial treatment particularly in younger patients...
Katzung says, "It is effective as monotherapy in mild parkinsonism and can be used together with levodopa in more advanced disease."

Not sure if that fact would ever change the DOC answer from Levodopa + Carbidopa...

Last edited by phlebgirl; 05-04-2014 at 01:44 PM.
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radkur (05-04-2014)



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