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Old 05-16-2014
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Default Haptoglobin

Is haptoglobin decreased in intra plus extravascular hemolysis or only intravascular?
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Old 05-16-2014
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Search Haptoglobin

I am not 100% sure, but I think that Haptoglobin levels are decreased in intravascular hemolysis and remain normal in extravascular hemolysis. Haptoglobin is found in your circulation, simply "waiting" for any free Hb so it can bind to it (since Hb is toxic in your blood, and Haptoglobin try to act as a last measure to "save" the free Hb which is being released by the destroyed RBC in peripheral blood (intra)). On the other hand, extravascular hemolysis is all in your spleen involving macrophages phagocytosing abnormal RBCs. There is no Haptoglobin involvement there, hence the normal levels

Hope this makes sense, if anyone else has a better or more correct explanation let me know.
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Old 05-17-2014
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I disagree, if such an important difference existed, test makers would have used it over and over.

Anyways, according to MEDSCAPE, it makes no difference


Decreased or absent haptoglobin levels are seen in the following conditions:[1, 2]

Intravascular hemolysis (hereditary spherocytosis, pyruvate kinase deficiency, autoimmune hemolytic anemia, transfusion reactions)
Extravascular hemolysis (intraperitoneal hemorrhage)
Intramedullary hemolysis (thalassemias, sideroblastic anemias, megaloblastic anemias)
Genetics (haptoglobin is absent in 1% of whites and 4%-10% of blacks)
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