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Old 05-05-2011
iron's Avatar
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Blood Why thrombosis in antiphospholipid syndrome?

In antiphospholipid syndrome why is arterial and venous thrombosis present? It has antiIgG RBC antibodies that react with phospholipid and produce prolonged PT, which is spurious, doesn't produce bleeding, but what is the reason behind thrombosis?
It is just because of that antiphospolid antibodies?
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Old 05-13-2011
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Well, What I have understood so far is that lupus anti-coagulant binds with prothrombin to cleave it into more active ,prothrombin, that is associated with increase risk of arterial/venous thrombosis. The presence of both lupus anticoagulant and anticardiolipid anticoagulant show more risk then with one alone.
It's PTT that is prolonged.

Last edited by iron; 05-13-2011 at 10:18 AM. Reason: more lines to add
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Hematology-, Internal-Medicine-, Rheumatology-

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