Early Antibiotic Treatment useful to prevent Acute Rheumatic Fever but not Glomerulonephritis? - USMLE Forums
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Old 05-22-2011
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Question Early Antibiotic Treatment useful to prevent Acute Rheumatic Fever but not Glomerulonephritis?

I've just seen this question:

early penicillin treatment of strep pharyngitis can prevent which of the following sequelae:

a) post-streptoccocal glomerulonephritis
b) Acute Rheumatic Fever
c) both the above

the answer given was B. my question is... why not A too?
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Old 05-22-2011
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Default It's all about immunology!

Because each of those have a completely different immunology. Acute rheumatic fever is a type II cytotoxic hypersensitivity reaction, and can be prevented by eliminating the organism. Acute GN, on the other hand, is a type III immune complex hypersensitivity reaction that is not related to direct damage by the organism, but by "3rd party" factors which are complement and immune complexes.
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Old 05-23-2011
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Default hey

hey thanks dude
Quote:
Originally Posted by Haisook View Post
Because each of those have a completely different immunology. Acute rheumatic fever is a type II cytotoxic hypersensitivity reaction, and can be prevented by eliminating the organism. Acute GN, on the other hand, is a type III immune complex hypersensitivity reaction that is not related to direct damage by the organism, but by "3rd party" factors which are complement and immune complexes.
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Immunology-, Infectious-Diseases, Internal-Medicine-

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