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Old 12-18-2012
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Default hepatitis B infection question in UW

Hi friends . I have a question . what is the treatment of for acute hepatitis B infection? This patient is young and has HBs ag +ve , HBe ag+ve ,anti HBc Ig M and anti Hbs -ve . My question is why cant we give hep b vaccine and immunoglobulin . if not i acute phase should we give them some where down the lane ??? plz clarify on this
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Old 12-19-2012
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Not sure if I am correct, but the immunoglobulin and the Hep B vaccine you give in post exposure propylaxis because the patient knows the time of exposure and it's best to get the immunoglobulin and Hep B vaccine within one week because it is less effective after that. If it's not a post exposure case, like in the sample you gave, then the patient probably got infected 90 days before starting to get symptoms, so the immunoglobulin and the Hep B vaccine will not work because it's too late.

In acute Hep B infection you only treat the symptoms and it usually resolves in 3-4 wks.

When it's chronic Hep B, you have HBsAg positive for 6 months. You treat with interferon and lamivudine on moderate to severe chronic Hep B, in which the aminotransferases should be more than twice the upper limit of normal. I hope this was useful.
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