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When do we use Isoniazid Monotherapy for TB treatment?

7K views 22 replies 4 participants last post by  Novobiocin 
#1 ·
When will be Isoniazid + pyridoxine for 6 months answer for Tuberculosis Q

thank you
 
#2 ·
Latent tuberculosis

There are several treatment regimens currently in use:

  • 9H - Isoniazid for 9 months is the gold standard (93% effective).
  • 6H - Isoniazid for 6 months might be adopted by a local TB program based on cost-effectiveness and patient compliance. This is the regimen currently recommended in the UK for routine use. The U.S. guidance excludes this regimen from use in children or persons with radiographic evidence of prior tuberculosis (old fibrotic lesions) (69% effective).

A 2000 Cochran review containing 11 double-blinded, randomized control trials and 73,375 patients examined six and 12 month courses of isoniazid (INH) for treatment of latent tuberculosis. HIV positive and patients currently or previously treated for tuberculosis were excluded. The main result was a relative risk (RR) of 0.40 (95% confidence interval (CI) 0.31 to 0.52) for development of active tuberculosis over two years or longer for patients treated with INH, with no significant difference between treatment courses of six or 12 months (RR 0.44, 95% CI 0.27 to 0.73 for six months, and 0.38, 95% CI 0.28 to 0.50 for 12 months).[126]
 
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#11 ·
What do you do for close contact of someone with active TB but have a negative PPD ?
In other words- high pre-test probability with negative PPD ?
 
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