USMLE Forums - View Single Post - ACE Inhibitors effects on Aldosterone Renin and Bradykinin
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Old 11-22-2010
hardik221186 hardik221186 is offline
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Renin is released from kidney in response to
sympathetic stimulation(via β1-receptors)
renal artery hypotension
decreased sodium delivery to the distal tubules of the kidney.
Renin is a proteolytic enzyme which converts circulating angiotensinogen to Angiotensin 1, which is converted by ACE to Angiotensin 2.

So, by blocking ACE..... the level of Renin, Angiotensin 1 & Bradykinin should increase and the level of Angiotensin 2 & Aldosterone should fall.

and also loss of negative feedback of angiotensin 2 on AT receptor located on kidney. so increase in renin and angiotensin 1.
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mtoi (11-23-2010)