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Old 01-22-2011
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Default redistribution of lipid soluble drugs

to achieve a therapeutic effect u have to get a suitable amount/concentration of drug in blood or the targeted tissue ( CNS here)

so whan the drug is so diffusable then it would require a very high plasma concn to achieve an effective CNS conc and haothane family ossilates between the two compartment so it is hard to achieve onset of action fast.
hope this helps
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