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Old 01-05-2010
lemontea88 lemontea88 is offline
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Drug First Aid's Clindamycin mechanism

According to First Aid, clindamycin blocks peptide bond formation.

But when I read Kaplan's pharmaco, it says clindamycin acts just like macrolides, which is to inhibit translocation of peptidyl-tRNA. Only chloramphenicol is involved in disturbing the "peptide bond formation" event in bacterial protein synthesis.

What do you guys think? Does clindamycin act both during the peptide bond formation stage, and also the translocation stage?
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