I think the correct one is answer B:
since they don't specify, you assume that the sequences are written in a 5'-3' direction. The hibridizing (binding) segment to that oligonucleotide should be complementary to it, thus it should be 3'-ATGCTAGTATA-5'. But since they write it on a 5'-3' direction, you have to reverse it. Thus it becomes 5'- ATATGATCGTA-3', answer B.
Does it make sense?
Originally Posted by Farazdaq
TACGATCATAT is an oligonucleotide probe used to construct a cDNA library to study the transcriptome of genetically modified mice.
Which of the following coding strands will correctly hybridize with the probe in question?