a 44 year old female is found delirius late at night in the streets brought in by a young man who was kind enough to give her something sweet on the way to the hospital. BP is 130/80 pulse is 78 bpm. On examination she has nystagmus, she's ataxic and has limited eye movement. She then behaved...
What does insulin do to potassium and what does potassium do to insulin secretion is a concept that is frequently tested in USMLE Step 1.
Let's summarize here and I'd be happy if you enrich this thread with your valuable posts.
Insulin causes Potassium to shift into the cells thereby...
We all know Mudpiles which is a mnemonic for increased anion gap acidosis and it specifically stands for
Methanol, Uremia, DKA, Phenformin/Paraldyhide, Iron/INH/Inborn error of metabolism, Lactic acidosis, Salicylates.
Now how about the normal anion gap acidosis! In fact in USMLE they are more...
A-I Activates Lacat
B-100-Binds to LDL receptor mediates VLDL secretion
C-II -cofactor for lipoprotein lipase.
b-48- mediates chylomicrone secretion.
E- mediates Extra - remnant- uptake
Hopefully will help memory process
USMLE Step 1 questions frequently ask about these very high yield three enzymes.
They are called ABC enzymes as they all need
These three enzymes are all carboxylases:
Propionyl Co-A Carboxylase
Acetyl Co-A Carboxylase
I have been facing some questions that confused me and could not tell the difference between Myophosphorylase deficiency (McArdle) and the other one, Muscle Carnitine deficiency.
Please anybody can simplify the distinction, any quick tip for the exam?
Post and Poll Options were last updated on November 26th, 2013.
In this poll we vote for the Best Biochemistry review book specific for the USMLE Step 1 Exam.
Choice of Books Listed in the Poll
You will notice that larger textbooks of biochemistry are not listed here, we are voting for...
If the question stem describes a child with signs of chronic liver disease such as bleeding tendency, signs of liver cirrhosis, jaundice, elevated LFTs, ...etc.
Plus a noticeable change in behavior such as clumsiness or even some Parkinsonian symptoms.
Think Wilson's Disease immediately.
How to tell them apart?
They both common in Ashkenazi Jews
They both cause Cherry red spot
They both cause blindness
They both kill early in life
They both cause mental retardation
They both cause seizures
They both are autosomal recessive
They both are lysosomal storage disorders...
In response to a member's request in this thread
We made this diagram available
Have a look here
click image to enlarge
Here's a mnemonic to remind us of the heme synthesis steps
Ala placed in urine cup produces heme
Aminolevulinic Acid --> Porphobilinogen --> Uroporphyrinogen --> Coproporphyrinogen --> Protoporphyrin (Protoheme) ---> Heme
There are other intermediates in the long pathway but these are...
For the purposes of USMLE there are only two enzymes that require B12 as co-factor, these are:
The conversion of homocysteine into methionine via the enzyme homocysteine methyl transferase which uses N5 methyl THF as another substrate converting it to THF. Therefore, deficiency of vitamin B12...
If you are like me having difficulty memorizing the sequence then this might help
1 Q Before Complex Attacking Fires
1 = Complex I (NADH Dehydrogenase)
Q = Coenzyme Q (Complex II, Succinate Dehydrogenase feeding into it)
B = Cytochrome b/c1 (Complex III)
C = Cytochrome C
A = Cytochrome a/a3...