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  1. USMLE Step 1 Forum
    I find this so confusing sometimes, because they just seem so contradictory to each other! PTH 1) inc alpha-1 hydroxylase synthesis ---> Inc active Vit D 2) inc Ca uptake by early distal tubules 3) dec phosphate uptake -----> Phosphaturia So based on the above, it seems obvious that PTH is...
  2. USMLE Step 1 Forum
    In PKU we see that accumulation of toxic metabolites of phenylalanine causes mental retardation. The question is that why other regions of brain are not affected by these metabolites? for example why visual cortex is not influenced in this disease? or why neuroglia cells are intact in this case?
  3. USMLE Step 1 Forum
    That man is a GENIUS! Why couldn't my biochem professor teach like that? I now UNDERSTAND CLEARLY all the intricacies of Folate, B12, and clinical manifestations. It's one thing just to memorize it, but it's something else to really understand and appreciate it...pain free! You can tell he...
  4. USMLE Step 1 Forum
    I have two sets of Kaplan biochemistry videos 1. Latest by David seaston 2. Old ones by Lionel Raymond... Which one is better??
  5. USMLE Step 1 Forum
    how can increase in ammonia levels stops TCA cycle ?? its mentioned in fa pg 107
  6. USMLE Step 1 Forum
    what is rationale of giving leucine and lysine in Pyruvate dehydrogenase deifciency as mentioned in first aid pg 101 ?
  7. USMLE Step 1 Forum
    hey everyone , I hope you are doing well :) I have a question about the Biochemistry I have only Kaplan Biochemistry lecture note without video .. is it enough for step 1 or should i get the another book ? thanks for your advices :)
  8. USMLE Step 1 Forum
    can some one pleasssssse put some light on substrate level phosphorylation especially in glycolysis , like how many times it happens there...m forgetting it ....
  9. USMLE Step 1 Forum
    Most enzymatic reactions follow a hyperbolic curve (follow Michaelis-Menten kinetics); however, enzymatic reactions that follow cooperative kinetics (i.e., hemoglobin) have a sigmoid curve. friends, what is the meaning of this statement ...cooperative kinetcs...:scared:
  10. USMLE Step 1 Forum
    Feeling so depress.. Is there any way, to remember and also recall, Biochem...?? I just hate this subject now...!! Can anybody have an idea how to do biochem questions??? exam is in next month and it seems that i've forgotten everything..!!
  11. USMLE Step 1 Forum
    treatment for LNS is allopurinol but text says CNS complaints are NOT decreased. why ?:notsure:
  12. USMLE Step 1 Forum
    hey friends, activation of amino acids during translation needs 2 high energy bonds. one high energy bond lost in converting ATP > ADP , where is other lost ?
  13. USMLE Step 1 Forum
    collagen has internal hydrophobic sequence because it will be secreted ... what is the meaning of this ? anyone ?
  14. USMLE Step 1 Forum
    1. why avoid sorbitol ? i understand why not to give fructose,sucrose 2. why does ATP increases in fructose intolerant liver cell ? see attachment for reference .... thanks ! p.s. any relevant usmle step 1 q on similar topic ?
  15. USMLE Step 1 Forum
    Greetings again everyone. I had a query about a table on dyslipidemias in FA. Type IV is due to the oversecretion of VLDL. The table states that there will be elevated blood levels of TG (only) and that there will be increased VLDL. Aren't VLDLs composed of TG and Cholesterol? Wouldn't the...
  16. USMLE Step 1 Forum
    A neonate is born with ambiguious genitalia. The clitoris is enlarged. There is a single perineal opening anterior to the anus and nom masses are palpable in the labioscrotal or inguinal region. Cause of the ambiguity?? 1. Androgen insensitivity 2.21 hydropxylase def 3. mixed gonadal dysgenesis...
  17. USMLE Step 1 Forum
    Anyone that can pass the me the most recent biochemistry videos from CH5 to CH7, kind of get lost sometimes at understanding the PCR, and Blot stuff without the videos.
  18. USMLE Step 1 Forum
    Guys, mostly mentioned collagenopathies are OI, EDS, and alport syndrome on most step 1 prep resources. I saw other conditions on my histology book, such as: Kniest dysplasia kindler's syndrome multiple epiphyseal dysplasia ( MED ) schmid metaphyseal chondrodysplasia stickler's syndrome type...
  19. USMLE Step 1 Forum
    Does anyone know the best qbank for biochemistry questions? I know usmleworld is the best qbank out there, but kaplan biochem lecture notes are supposed to be pretty good.. im not sure which qbank would be better for biochem only.. uworld or kaplan? just wanna strengthen my biochem a lil more...
  20. USMLE Step 1 Forum
    Can some please explain this concept to me? According to First Aid, "The oxidized form of hemoglobin (Fe3) doesn't bind O2 as readily but has an increase affinity for CN- (cyanide). I thought that the oxidized form of hemoglobin (Fe3) has a higher affinity for O2 (oxygen) therefore creating a...
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