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  1. USMLE Step 1 Forum
    Why does the murmur of HCM decrease with hand grip?
  2. USMLE Step 1 Forum
    Anyone know mechanism how Acidosis, hypoxia and hypercapnia decrease contractility
  3. USMLE Step 1 Forum
    According to kaplan qbank in coarctation pressure tracing in thoraic aorta is greater then abdominal aorta which is due to increase in ANG-II as renal is not adequately perfused ... but i think pressure in thoracic and abd. aorta should be same as coarctation is proximal to thoracic aorta so...
  4. USMLE Step 1 Forum
    Increase stroke volume increases pulse pressure. HOW? If SV is increased then blood pumped by the heart is increased so systolic BP should also increase.. As more blood is now present in aorta so stretch on aorta increases which increases diastolic BP pulse pressure should be same.
  5. USMLE Step 1 Forum
    Pt. presented with history of sub-sternal pain that radiate to his left shoulder occurs at rest and pain improves when he gets up and move around also improve after taking nitroglycerin.. Likely cause of finding? 1) coronary artery spasm 2) coronary artery thrombosis 3) coronary artery embolism...
  6. USMLE Step 1 Forum
    1) If total peripheral resistance (TPR) decreases ----- venous return decreases...because of decrease in preload (peripheral pooling of blood)....for example as in case of venodilators which decrease TPR & causing blood to pool in peripheral vessels, thereby decreasing venous return . 2) If...
  7. USMLE Step 1 Forum
    I'm a bit confused. There were 2 Qs in UWorld. One of them meant that the vegetations in Acute bacterial endocarditis caused by S aureus has valvular vegetations made of platelets & fibrin (which I expected to be inflammatory deposit containing bacteria since they embolize to form septic...
  8. USMLE Step 1 Forum
    Pathoma vids are saying that tunica media is missing in berry aneurysms and Goljan says Internal elastic lamina is missing...looking at histology internal elastic lamina is "A fenestrated layer of elastic tissue that is the outermost part of the intima of an artery. Also called internal elastic...
  9. USMLE Step 1 Forum
    Hey In First Aid, Varicose Veins: Thromboembolism is rare, In medscape its considered as a risk factor ? So Which One is Right?
  10. USMLE Step 1 Forum
    when person stands from lying position what change will you observe in central venous pressure pressure gradiant venous return
  11. USMLE Step 1 Forum
    In goljan pathology he says that fibrinous pericarditis manifests with precordial chest pain which disappears when leaning forward and appears back when leaning back. can someone explain this why this happens?:) Thanks in advance
  12. USMLE Step 1 Forum
    Anyone can explain this physiological maneuvers with detailed explanations please. See attached table.
  13. USMLE Step 1 Forum
    Hypokalemia is a risk factor for Torsade de pointes , where as hyperkalemia is not ! Has anyone come across the CONCEPT behind these electrolyte changes causing this type of arrythmia ?? Memorizing them simply just doesn't work :toosad:
  14. USMLE Step 1 Forum
    how pulmonic regurgitation increase wedge pressure and pulmonic stenosis decrease it? can someone explain it please :plz::plz:
  15. USMLE Step 1 Forum
    In Aortic Stenosis, "systolic ejection phase" decreased...why ??? ...need detailed explanation ....thx
  16. USMLE Step 1 Forum
    Hello! I'm a bit confused with the circulation. Just to clarify I THINK this is how it goes according to FA / Kaplan 1) Umbilical Vein -> Ductus Venosus -> IVC -> Foramen Ovale -> Left Atria -> Left Ventricle ->Aorta. (FA Version) 2) It was mentioned in Kaplan 2010 Umbilical Vein -> Right...
  17. USMLE Step 1 Bits & Pieces
    ↑ Stroke Volume = ↑ Pulse pressure ↓Compliance of the arterial (Aorta) = ↑ Pulse pressure ↑ Stroke Volume = ↑ Systolic pressure ↓Compliance of the arterial (Aorta) = ↑ Systolic pressure ↑ Stroke Volume = ↓ Diastolic pressure (TPR) ↓Compliance of the arterial...
  18. USMLE Step 1 Forum
    hi every body can some explain for me why decreses in afterload and preload increase the intensity of HCM ?
  19. USMLE Step 1 Forum
    I think ther should be hypertension becuz due to decrease fillin cardiac output will be low so angiotensin system should increase BP..
  20. USMLE Step 1 Forum
    can anyone tell me what is the most common organism responsible for causing infective endocarditis? Goljan says Strep. viridans and Uworld says Staph aureus