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  1. USMLE Step 1 Forum
    Is fragile X syndrome dominant or recessive? FA says its recessive, Goljan too, but Kaplan says its x-linked dominant, which one should I trust now? I'm confused, can you help me?
  2. USMLE Step 1 Forum
    Goljan book says Autosomal dominant The same guy in his audios says Autosomal recessive :rolleyes: Does anyone know the right mode of inheritance ? Please tell me where you got your answer from, the internet itself has given me different answers ..
  3. USMLE Step 1 Forum
    Ok, this one is probably a very overlooked topic but a very High Yield one, so lets start a discussion and postings of useful links and Vids explaining USMLE Lab Techniques found in Genetics/Immuno/Biochem etc. ( PCR, Blots, Assays, Coombs for instance) Kindly post useful videos that you have...
  4. USMLE Step 1 Forum
    Retroviruses are used as vector to transfer cDNA in gene therapy BUT retroviruses only have RNA so how can we use them to transfer DNA????
  5. USMLE Step 1 Forum
    Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell...
  6. USMLE Step 1 Forum
    Huntington's patients have a significantly lower chance to develop cancer. why ?
  7. USMLE Step 1 Forum
    Hi there Im referring to Chapter 5 Gene Mapping in the Genetics section. For question 5 at the backside in the answers and explanations, the answer is right and I agree with it but the explanation is confusing, it says that all the individuals from 2-6 are recombinants between these loci of ABO...
  8. USMLE Step 1 Forum
    FA mentions that genetic code is universal and exception is human mitochondria. I did not get this. Please explain....
  9. USMLE Step 1 Forum
    father is robertsonian carrier mother is normal child has downs what is the risk of another child with downs ?
  10. USMLE Step 1 Forum
    Hello everyone a quick question let's say a woman inherits an X linked recessive disease and the inactivation of the NORMAL x gene occurs making the x linked gene active does this woman express the gene or not? Im reading she doesn't express it because she has another X chromosome so hence the...
  11. USMLE Step 1 Mnemonics
    ABCDEFGH LOW A - Agammaglobulinemia (Bruton's) B - Blindness to colors C - Chronic granulomatosus disease D - Dystrophies (Duchenne's and Becker's) E - hEmophilia (A and B) F - Fabry's disease G - G6PD deficiency H - Hunter's syndrome L - Lesch-Nyhan syndrome O - Ornithine transcarbamoylase...
  12. USMLE Step 1 Forum
    Variable in heritance due to locus heterogeneity pg 108 first aid plz explain what it means ?
  13. USMLE Step 1 Forum
    what is the most common inherited cause ? and genetic cause of mental retardation, to my surprise ans to both of htem diff as per book i referred to. so what you think is the ans. what is the diff in above 2 questions ? :p
  14. USMLE Step 1 Forum
    A 45-year-old woman (III, 7) comes to the physician for routice examination. Several of her family members have hereditary telangectasia. A pedigree is shown. Physical examination and full medical evaluation show no abnormality. Which of the following best explain for this patient's health? A)...
  15. USMLE Step 1 Forum
    A 37 y/o female has a son with DMD She has had blood tests to see if she is a carrier and she is not. She is now pregnant with another son and has also had genetic testing done via cvs on the fetus for DMD which has come back negative. There is no family history, she has 5 healthy brother and 4...
  16. USMLE Step 1 Bits & Pieces
    OK, This is really confusing and difficult to remember. Let me list them here; Follicular Lymphoma: Chromosome 14 (Ig heavy chain) and Chromosome 18 (bcl-2 inhibit apoptosis) Burkitts Lymphoma: Chromosome 14 (Ig heavy chain) and Chromosome 8 (C-myc oncogene) Mantle Cell Lymphoma...
  17. USMLE Step 1 Forum
    A 40-year-old man presents to the emergency department with 8 hours of uncontrollable epistaxis. In the past 3 months he has felt increasingly fatigued, and has lost 11.3 kg (25 lb). On physical examination, he is pale and is found to be bleeding from his gingivae. He also has diffuse petechiae...
  18. USMLE Step 1 Forum
    Can anyone please explain these terms for me : Adjacent segregation and Alternate segregation Reciprocal translocation and Robertsonian translocation Recently came across this question in kaplan Qbook, 1st test biochem Q-18, if someone has come across it and explain it in context to this...
  19. USMLE Step 1 Forum
    A 1-day-old neonate has hemolytic disease of the newborn. The parents are both Rh-positive, but IgG isohemagglutinins are found in the mother's blood. Which of the following parental blood types is most likely to cause this condition? A. Mother: A & Father: O B. Mother: AB & Father: O C...
  20. USMLE Step 1 Forum
    I'm a bit curious as to why the answer isn't RNA polymerase, since it's responsible for causing transcription from DNA --> RNA. However, the answer is C for this question.