Hi Clarifying for synthesis of globin chain alpha gene at chromosome 16 beta gene at chromosome 11. Am I correct ? I read one notes and mention is different. Thanks

I found this awesome summary of anemias to know for step 1, along with some basic heme definitions and such. I hope you find it useful too!

A 32-year-old nulliparous female with a history significant for SLE and two miscarriages presents with localized tenderness of gradual onset, with erythema, along the path of a superficial vein in her foot. Although the symptoms are indicative of superficial thrombophlebitis, her PT is within...

An 82 y/o woman with blood group A inadvertently receives blood group B blood. She does not develop a hemolytic transfusion reaction. This is most likely due to ? A. absence of isohemagglutinins with old age B. a defect in cellular immunity C. Bruton's agamaglobulinemia D. antithrombin III...

Can someone please post a good image along with explanation of what is important in the smear findings of a leukemoid reaction. I understand that we are looking for a Left shift and a high WBC count but I cannot find good smear images for it. Thanks so much =)

A 60-year-old male presents with malaise. An irregular finding on his CBC leads to a more detailed workup. Flow cytometry of a blood sample reveals a preponderance of cells expressing CD5, CD19, CD20, and CD23. The patient is most likely to have: Adult T-cell leukemia Anaplastic ALK+...

A 54-year-old Caucasian male diagnosed with HIV infection two years ago develops cough, low-grade fevers and hepatosplenomegaly. He has lost eight pounds over the past month. A light microscopy image of a bone marrow aspirate is shown below. click image to enlarge Which of the following is...

1 - Which coagulation factor it acts on? 2 - How it is monitored? PT/PTT?

Hi can someone explain why we have polycythemia in Hepato Cellular Carcinoma and Renal Cell Carcinoma ? Thanks :-)

1-do we have high retic count in Beta thalassemia major? since we have hemolysis i expect high RET count BUT i read this case from FA Q&A ,,a 7 months boy with beta thalassemia and jaundice but 0.3% retic count!! 2-and i want to know why there is high risk of P.HTN in B thalassemias??

i just read this q from FA ; a boy with diagnosis of aplastic anemia ; his lab results ;low platlet and anemia but the wbc count is 27,000.is it possible to have leukocytosis in aplastic anemia?! even if the aplastic anemia is due to an infection such as EBV,HV,ZOSTER...still can we have...

You are asked to counsel a married couple expecting a baby. They are both fit and well, with no previous medical history. They both originate from South East Asia, and have no family history of birth abnormalities. There are no abnormalities on examination. Results are shown below: MALE Hb...

A patient presents to the ER with head trauma. An x-ray of the skull reveals no fracture, but the skull appears to have a "crew cut" appearance. Which of the following conditions could result in this finding? A. microangiopathic hemolytic anemia B. hereditary spherocytosis C. α-thalassemia D...

A patient comes to you with complaint of fatigue, dyspnea on exertion and loss of sensation in his lower extremities, upon neurological examination the patient has decreased vibratory sensation in his both legs and Rhomberg's test is +ve. lab findings shows methlymalonyaciduria and increased...

Can someone please explain me how warfarin can cause transient hypercoagulation? I have read repeatedly the fact that it inactivates Protein C but i am not able to understand convincingly how Protein C and Factor VII half-lives cause it. Thanks in advance.

MACROPHAGE 1)Lipid laden macrophage(Foam cells) = 1)Hyperlipidemia & 2)Atherosclerotic plaques. 2)Hemosiderin laden macrophage(Heart failure cells) = CHF. 3)Macrophages containing debris from ingested Lymphocytes(Tingible body macrophage) = Benign reactive lymphadenitis. 4)Macrophages...

In firstaid 2010 page 348: lead poisoning enzyme affected is "ALA dehydratase" BUT In errata FA (from firstaid website) it says replace it with " ALA synthase " which one is correct plz clarify , thanks

Hi All, I try to memorize coagulation cascade and factors long time but without any big success :notsure: Anyway I mixed up with this... Could someone give me an idea - how memorize it?

For people who already took the exam and those Who know almost everything about the exam I have a ?????? Do they ask about FAB classification of Myelogenous Leukemias. Is that something that I should learn good????? I had already like 2 or 3 ??? in Kaplan Qbank STEP 1

A hodgkin B waldenstrom's macroglobulinemia C burkitt's lymphoma D histiocytosis x E sezary syndrome Age 54 male anemia normocytic esr elevated lymphadenopathy generalized hepatosplenomegaly hyperviscosity syndrome serum protein electrophoresis abnormal