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  1. USMLE Step 1 Forum
    With malignant hyperthermia, it is due to the Ryanodine receptors opening up. Treatment will be Dantrolene which blocks the Ryanodine receptors Since the Ryanodine receptors are opening up does this make the DHP receptor to open up as well?
  2. USMLE Step 1 Forum
    A patient with manic depressive disorder is treated with lithium, which slows the turnover of inositol phosphates and the phosphatidyl inositol derivatives in cells. Which of the following protein kinases is most directly affected by this drug? A. Protein kinase C B. Receptor tyrosine kinase C...
  3. USMLE Step 1 Study Partners
    hi everyone, Does anybody have molecular biology & biochemistry offline qs link? any help regarding this will be highly appreciated.my e mail id [email protected]
  4. USMLE Step 1 Forum
    A gene encodes a protein with 150 amino acids. There is one intron of 1000 bps a 5'-untranslated region of 100 bps and a 3'-untranslated region of 200 bp. In the final processed mRNA, how many bases lie between the start AUG codon and the final termination codon? A. 1,750 B. 750 C. 650 D. 450...
  5. USMLE Step 1 Forum
    Folks who have took the exam already Can you guys please throw some light on what areas of Molecular /Biochem and Anatomy do we focus upon. There seems to be an increasing trend of being tested in these subjects. Thank you.
  6. USMLE Step 1 Forum
    Hey guys can you plz all tell whats the popular opinion on doing High Yield Cell and Molecular Biology ? The books has so much info on different genes and all..cant do it all. If one has to selected chapters from that book than what would those be? Plz help and reply.
  7. USMLE Step 1 Forum
    1. Is Tay-Sachs disease a frameshift mutation or a mutation in splice sites? 2. Is beta thalassemia a nonsense mutation or a mutation in splice site? please answer with explanations.
  8. USMLE Step 1 Forum
    A farming couple in Nothern Michigan consult their physician about severe skin rashes and ulcers noted over the past year. They also have lost many cattle over the past year, and claim that their cattle feed changed in consistency and smell about 1 year ago. Chemical analysis of the feed shows...
  9. USMLE Step 1 Forum
    Retroviruses are used as vector to transfer cDNA in gene therapy BUT retroviruses only have RNA so how can we use them to transfer DNA????
  10. USMLE Step 1 Forum
    FA mentions that genetic code is universal and exception is human mitochondria. I did not get this. Please explain....
  11. USMLE Step 1 Forum
    Hi, My exam is 2 weeks away. I am solving NBMEs offline n the trend is increasing no. Of molecular biology questions. So plz suggest a good source to gather good knowledge abt it. Coz FA is not enough. Thanks.
  12. USMLE Step 1 Forum
    Sickle cell anemia is caused by a missense mutation in codon 6 of the beta-globin gene. Codon number 5 6 7 8 Normal allele CCT GAG GAG AAG Mutant allele CCT GTG GAG AAG A man with sickle cell disease and his phenotypically normal wife request genetic testing because they are...
  13. USMLE Step 1 Forum
    James K. is a Huntington disease patient who has recently been institutionalized and requires constant nursing care. His wife is unaffected, and they have a 38-year-old daughter, Delia, who has 4 children ranging in age from 8 to 15 years. Delia wishes to know whether she has inherited the...
  14. USMLE Step 1 Forum
    what is difference in hnRNA and pre-mRNA, in my opinion both are same ...
  15. USMLE Step 1 Forum
    Dyskeratosis congenital (DKC) is a genetically inherited disease in which the proliferative capacity of stem cells is markedly impaired. The defect has been traced to inadequate production of an enzyme needed for chromosome duplication in the nuclei of rapidly dividing cells. Structural...
  16. USMLE Step 1 Forum
    Hello everyone, I have step 1 in less than a month. I have done all nbme self assessments. The behav sciences( mainly doc patient interactions and ethics), mol bio, immunology ques on nbme self ass. are very difficult. I almost always mark them wrong. They are very different and much difficult...
  17. USMLE Step 1 Bits & Pieces
    original post- by zahque After hearing about how high yield the second messengers and receptor mechanisms were for step 1 for the millionth time (and realizing that I had no idea how atrial natriuretic peptide actually works), I decided to put together this little "cheat sheet" I basically went...
  18. USMLE Step 1 Forum
    Hello everyone! I'm having a terrible time with the secondary messengers and their effects on muscle contraction, specifically their role in contractions in the different types (smooth, skeletal, cardiac). 1. Could someone please explain the roles and onward cascades of cAMP and cGMP in smooth...
  19. USMLE Step 1 Forum
    Can any one please explain for the meaning of those in the chromatin structure? Thank you!
  20. USMLE Step 1 Forum
    how do we have dUMP (deoxyuridine monophosphate),dUDP and dUTP when we know that deoxy sugars are found only in DNA and URACIL base is found only in RNA?? i mean to say it should be simply UMP,UDP,UTP .....somebody plz clear my doubt:indifferent::indifferent:
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