[Seetal]

A 20-year-old man comes to the physician's office for a scheduled health maintenance examination. His father died of a myocardial infarction at age 55 years. Physical examination shows a tendon xanthoma on the elbow. His serum total cholesterol concentration is 360 mg/dL. A mutation is most likely to be found in which of the following genes?

(A) apoA2
(B) apoC2
(C) apoε4
(D) LDL receptor
(E) VLDL receptor

 

[achistikbenny]

The answer is most likely D. LDL receptor mutation causes development of atherosclerosis , xanthomas and arcus corneae.

 

[khanar]

yes, that's right all other mutations cause high triglyceride rather than high cholesterol or LDL

 

[HouseWannabe]

D

This is Hypercholestrolemia most likely IIa, and the most likely complication is Heart attacks which his dad died from. Plus extensor tendon xanthomas are only in cholesterol associated hyperlipidemias.

 

[Seetal]

yes u're all ryte. the answer is D. thanks for the explanations!