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Discussion Starter #1
A 25 year old female patient presented with fatigue
Peripheral blood film showed this

bloodfilm.JPG
click image to enlarge

What cell markers are seen on these cells?
a- CD4
b- CD8
c- CD21
d- CD15
e- CD14
 

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Hi Sarah, I'm still not clear about this one. From what I read EBV binds to Cd21 and that's how it infects the B-cells that later then trigger the T-cell CD8 reaction that attacks the infect B-cells. So shouldn't the markers of the cells in the pic be the ones that are found on the B-cells (Cd21)??
 

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Discussion Starter #6
Hi Sarah, I'm still not clear about this one. From what I read EBV binds to Cd21 and that's how it infects the B-cells that later then trigger the T-cell CD8 reaction that attacks the infect B-cells. So shouldn't the markers of the cells in the pic be the ones that are found on the B-cells (Cd21)??
Reactive lymphocytes are T lymphocytes, not B lymphocytes.
This is the story in any viral infection it's just has a fancy name in EBV infection.
B lymphocytes act as Ag presenting cells pulling viral peptides up to MHC class I molecule on the surface that would then get recognized by CD8 cells and that's why CD8 cells get proliferated (immune response).
 

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i know this is a really old thread but you can see the darkness on the edges of the cell as it comes into contact with RBCs which is characteristic of CD8 T cells
 
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