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#### indian

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Can anybody tell me how do we get 32 ATPs from each glucose molecule
I can't understand the calculation and also there's two questions about it in USMLE Consult

• Usmle16Forall

#### indian

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It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

#### rasheed

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Each glucose gives two pyruvates
I think level1 confusion stems from the fact that he forgot that each glucose gives two pyruvates

Always remember the glycolysis equation

Code:
``Glucose + 2Pi + 2ADP + 2NAD = 2 Pyruvate + 2ATP + 2NADH + 2H + 2H2O``

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very good job ... but ....

It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead
thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP am i right ?! #### rasheed

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thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP am i right ?! You are absolutely right • Laurentiu

#### forawee

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You are absolutely right Betro. Glycolysis can produce either 6 or 8 ATPs, so by the end of KREBS CYCLE (36 or 38) depending on wt ATP produced from glycolysis. #### drnirajmavani

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It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead
i think malate shuttle produces 3 atp s as it uses nadh and G3P shuttle produces 2 as it uses FADH2

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