32 ATPs per glucose molecule?

17567 Views 7 Replies 6 Participants Last post by frenkert, Apr 7, 2012

indian

Discussion Starter · Sep 4, 2009

Can anybody tell me how do we get 32 ATPs from each glucose molecule
I can't understand the calculation and also there's two questions about it in USMLE Consult

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indian

Discussion Starter · #2 · Sep 4, 2009 (Edited by Moderator)

It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

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rasheed

· #3 · Oct 13, 2009

needtopass said:
Each glucose gives two pyruvates

I think level1 confusion stems from the fact that he forgot that each glucose gives two pyruvates

Always remember the glycolysis equation

Code:

Glucose + 2Pi + 2ADP + 2NAD = 2 Pyruvate + 2ATP + 2NADH + 2H + 2H2O

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Betro Sadek

· #4 · Oct 14, 2009

very good job ... but ....

needtopass said:
It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP

am i right

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rasheed

· #5 · Oct 14, 2009

Betro Sadek said:
thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP

am i right ?!

You are absolutely right

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forawee

· #6 · Dec 5, 2010

You are absolutely right Betro. Glycolysis can produce either 6 or 8 ATPs, so by the end of KREBS CYCLE (36 or 38) depending on wt ATP produced from glycolysis.

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drnirajmavani

· #7 · Apr 16, 2011

needtopass said:
It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

i think malate shuttle produces 3 atp s as it uses nadh and G3P shuttle produces 2 as it uses FADH2

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frenkert

· #8 · Apr 7, 2012

doesnt the g3p shuttle produce 1,5 mol atp a nadh-->fadh2 conversion?

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