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Question 1:
When a person has Measles, antibodies are produced which provide protection against Measles virus but no other viruses. What is the role of Measles virus proteins in creating this specificity?
A. Determine which clones of lymphocytes with antigen-specific receptors will proliferate.
B. Prevent negative selection of immature T lymphocytes with measles-specific receptors.
C. Promote negative selection of immature B lymphocytes with self-reactive receptors.
D. Determine which V/D/J DNA segments are used to assemble antibody genes.
E. Specify nucleotides added at DNA splice joints during immunoglobulin gene assembly.
Question 2:
A child who has had one previous immunization against tetanus is given the second immunization in the recommended series, three months later. In what way would you expect the immune response to the second immunization to differ most significantly from the response to the first?
A. The second response will be slower, but more prolonged.
B. The second response will be larger, but shorter.
C. The second response will produce more antibody, but after a longer lag.
D. The second response will be primarily cell-mediated, the first primarily antibody-mediated.
E. The second response will produce a higher ratio of IgG to IgM.*
Question 3:
A patient has a respiratory allergy to oak pollen and asks about the possibility of desensitization by immunization, such as is possible for bee-sting allergy. You tell the patient that this mode of therapy works less well against respiratory allergies than against insect-venom allergies. What creates this difference in effectiveness?
A. Pollen antigen for desensitization is not available.
B. Insect venoms are more immunogenic than pollen.
C. IgA in nasal secretions binds pollen, preventing binding of IgG.*
D. Mast cell degranulation plays little role in respiratory allergies.
E. IgG blocking antibody has less access to pollen than to insect venom.
Question 4:
Test reaction Result
Patient erythrocytes + anti-A serum
No Agglutination
Patient erythrocytes + anti-B serum
Agglutination
Patient erythrocytes + anti-Rh0(D) serum
No Agglutination
Patient serum + Type A erythrocytes
Agglutination
Patient serum + Type B erythrocytes
No agglutination
Patient serum + Type O erythrocytes
No agglutination
What is the patient's blood type?
A) A, Rh positive
B) A, Rh negative
C) B, Rh positive
D) B, Rh negative
E) AB, Rh negative
When a person has Measles, antibodies are produced which provide protection against Measles virus but no other viruses. What is the role of Measles virus proteins in creating this specificity?
A. Determine which clones of lymphocytes with antigen-specific receptors will proliferate.
B. Prevent negative selection of immature T lymphocytes with measles-specific receptors.
C. Promote negative selection of immature B lymphocytes with self-reactive receptors.
D. Determine which V/D/J DNA segments are used to assemble antibody genes.
E. Specify nucleotides added at DNA splice joints during immunoglobulin gene assembly.
Question 2:
A child who has had one previous immunization against tetanus is given the second immunization in the recommended series, three months later. In what way would you expect the immune response to the second immunization to differ most significantly from the response to the first?
A. The second response will be slower, but more prolonged.
B. The second response will be larger, but shorter.
C. The second response will produce more antibody, but after a longer lag.
D. The second response will be primarily cell-mediated, the first primarily antibody-mediated.
E. The second response will produce a higher ratio of IgG to IgM.*
Question 3:
A patient has a respiratory allergy to oak pollen and asks about the possibility of desensitization by immunization, such as is possible for bee-sting allergy. You tell the patient that this mode of therapy works less well against respiratory allergies than against insect-venom allergies. What creates this difference in effectiveness?
A. Pollen antigen for desensitization is not available.
B. Insect venoms are more immunogenic than pollen.
C. IgA in nasal secretions binds pollen, preventing binding of IgG.*
D. Mast cell degranulation plays little role in respiratory allergies.
E. IgG blocking antibody has less access to pollen than to insect venom.
Question 4:
Test reaction Result
Patient erythrocytes + anti-A serum
No Agglutination
Patient erythrocytes + anti-B serum
Agglutination
Patient erythrocytes + anti-Rh0(D) serum
No Agglutination
Patient serum + Type A erythrocytes
Agglutination
Patient serum + Type B erythrocytes
No agglutination
Patient serum + Type O erythrocytes
No agglutination
What is the patient's blood type?
A) A, Rh positive
B) A, Rh negative
C) B, Rh positive
D) B, Rh negative
E) AB, Rh negative