USMLE Forums banner

A1AT deficiency and liver cirrhosis

738 Views 1 Reply 2 Participants Last post by  elMuchacho
Hello everyone,

I have a question I hope someone can answer it.

I understand that A1AT deficiency is due to misfolding of the mutated protein and it accumulates in the liver leading to cirrhosis.

BUT how is this misfolded, mutated protein damaging to the liver? what is the pathology that leads to this liver cirrhosis?

  • Like
Reactions: 1
1 - 1 of 2 Posts
1 - 1 of 2 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.