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The amount of antibodies in the donors blood is not enough to cause a reaction clinically. The problem arises not when the antibodies meet the antigen but when the lymphocytes do, get activated and start a type2 reaction, which happens if you donate those as been said by steptaker in bone marrow transplants.

Putting it simply, to avoid confusion :confused: ... the donor donates only the antigen not the antibodies, the recepient has both ;).

So in your example the serum of an O person which contains the antibodies is given only when he is the recepient.
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