[ecgram]

1-day-old neonate has hemolytic disease of the newborn. The parents are both Rh-positive, but IgG isohemagglutinins are found in the mother's blood. Which of the following parental blood types is most likely to cause this condition?

Mother blood group - Father blood group
(A) A - O
(B) AB - O
(C) B - A
(D) B - O
(E) O - AB

 

[drmodi44]

E??

E) O AB....
as mother lack both A and B antigens...she can produce immunoglobulins if she comes in contact with fetal blood which can be of either A or B or AB.....

 

[ecgram]

yup true can u explain it in lilbit more detail i am little bit confused

 

[drmodi44]

this type of reaction occurs mostly in o positive pregnant women....normally BG O pregnant women hs both Anti A and Anti B antibodies but they r of IgM type so can not cross placenta....but she can produces IgG in response to A or B antigen from fetus....
here mother is O + so her genotype would be OO
and father is AB so genotype AB
so fetus will hv either OA or OB genotype...leading to either A or B antigens....
when mother comes in contact with fetal blood...she will produces IgG antibodies to either A antigen or B antigen....cross placenta..and lead to HDN....

hv a look at this site...
http://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(ABO)

 

[ecgram]

thanks alot got it

 

[drsue]

i'll go for E