Because even though ACE inhibitors increase overall kidney perfusion, they decrease glomerular perfusion. That's great in something like diabetic nephropathy where glomerular hypertension is accelerating the glomerulosclerosis - but it could be dangerous in something like bilateral renal artery stenosis, where the atII-constricted efferent arteriole is the only thing maintaining the glomerular pressure that is needed to maintain renal function.
ACE inhibitors Nephrotoxic or Nephroprotective
In Goljan it is given,
that ACE inhibitors are beneficial in diabetic nephropathy cause they maintain renal perfusion beyond efferent arteriole and thereby supplying blood to kidney parenchyma.
but in UW its given ACE mediated nephrotoxity is due to :
"RENAL HYPOPERFUSION"
??????????????
:notsure::notsure::notsure::notsure:
that ACE inhibitors are beneficial in diabetic nephropathy cause they maintain renal perfusion beyond efferent arteriole and thereby supplying blood to kidney parenchyma.
but in UW its given ACE mediated nephrotoxity is due to :
"RENAL HYPOPERFUSION"
??????????????
:notsure::notsure::notsure::notsure:
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