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Does anyone know why in Adenosine deaminase deficiency cause low lymphocyte count? TIA
adenosine deaminase deficiency --> inability to breakdown adenosine --> accumulation of adenosine, converted to ATP and consequently dATP --> feedback inhibition of ribonucleotide reductase (excess product turns off enzyme) --> impaired lymphocyte synthesis

hope this helps
 

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Discussion Starter #3
Thank you for the response. I just saw on FA 2016 version that it mentions accumulation of dATP causing toxicity in lymphocytes.
 
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