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ADP Ribosylation Bacterial Toxins

13K views 8 replies 4 participants last post by  Lostcause 
#1 ·
ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein, a reaction important in cell signaling.
But there are bacterial toxins that act by ADP ribosylation.

Here's the mnemonic
cAMP

c = Cholera (increases cAMP in intestinal cells causing diarrhea), it acts on G-protein

A = Anthrax

M = rotated E = E Coli (heat stable enterotoxin)

P = Pertussis toxin

speaking of the heat labile toxin, let's remember that Labile is just like Air (activates cAMP) while heat stable means stable like ground (activates cGMP)

Note that the cAMP mnemonic above is about ADP ribosylating toxins that work through cAMP activation only. There are 2 more ADB ribosylating bacteria and these are Pseudomonas and Diphtheria toxins both of work on EF-2 factor and inhibit translocation in protein synthesis.
 
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