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75 y.o. with a lot of drug for HTN, OA, and cholesterol. Which age-related decline in the following pharmacokinetic process is most likely to affect this treatment?
A. gastric absorption
B. hepatic glucorunidation
C. hepatic oxidative metabolism
D. protein binding in the serum
E. Renal tubular secretion

---> Phase1 is decreased in the elderly so I thought C is the answer, but at the same time renal function is decreased so E might also be the answer.... Does anyone know what's the right answer here?
 
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