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i have a question
in a normal lung , what secrets alpha 1 anti trypsin that protects the lung from Emphysema??
 

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Alpha-1 antitrypsin

I think,as it is a protease inhibitor, it should be synthesized in all cells to protect from the effect of inflammatory cells during inflammation.
But its deficiency is most obvious in the lung and liver because they are subjected to frequent infections especially the lung and toxic metabolite in case of the liver.
 

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LIVER CELLS synthesize and secrete it and it works in the lung , it's defeciency is caused by defective protien transporter into the blood stream , so it will accumulate in the liver and cause CIRRHOSIS , and will not reach the lung , so it will not compensate for Elastase secreted by activated macrophages causing PANLOBULAR EMPHYSEMA ..
 
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