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i think you have no other option other than memorizing.

to understand the concept of spontaneous and nonspontaneous first understand the change in energy which equals energy of products - energy of substrate.
if you encounter a negative value for deltaG(change in free energy) it meas that the energy of substrates is greater than that of products. understand that things have a natural tendency to acquire a low energy state so if the energy of substrate if higher than formation of the products is 'favored' . in other words, we can say that under standard conditions , the reaction is spontaneous and irreversible.
the reaction
fructose6phos.........................>fructose1,6phos
catalysed by hepatic phosphofructokinase-1 has a G0 value of -3.5 kcal/mol. This value indicates that under standard conditions formation of the products is 'favored' the reaction is spontaneous and irreversible so cant not be used for gluconeogenesis and some alternative pathway must be there to bypass this irreversibbility . hope this makes sense .
 
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