[studyhard]

Is amiodarone induced hypothyroidism causing raised or decreased prolactin?

Could anybody please explain?


Thanks.

 

[FSUSTC]

Is amiodarone induced hypothyroidism causing raised or decreased prolactin?

Could anybody please explain?

Thanks.

Hypothyroidism causes hyperprolactinemia , as decrease Thyroid hormon causes .. Increase TRH , which have stimulatory effect on lactotrophs causes increase prolactin secretion ... causes s/s of hyperprolactinoma ..... In that Rx of hyperprolactinoma is thyroxin ....

 

[Sabio]

Also read here
http://www.usmle-forums.com/usmle-step-2-ck-forum/1452-amiodarone-hypo-hyper-thyroidism.html

 

[studyhard]

Hypothyroidism causes hyperprolactinemia , as decrease Thyroid hormon causes .. Increase TRH , which have stimulatory effect on lactotrophs causes increase prolactin secretion ... causes s/s of hyperprolactinoma ..... In that Rx of hyperprolactinoma is thyroxin ....

Thanks.

I know that hypothyroidism in general can cause hyperprolactinemia. But, is there anything special about amiodarone induced hypothyroidism effect on prolactin?

See this:
http://www.ncbi.nlm.nih.gov/pubmed/3427795

I ask this because I want to know how to differentiate amiodarone induced hypothyroidism and other cause of hypothyroidism by reviewing the lab result. I am suspecting that 'prolactin' may be the key?

Thank you very much. Appreciated.

 

[studyhard]

Also read here
http://www.usmle-forums.com/usmle-step-2-ck-forum/1452-amiodarone-hypo-hyper-thyroidism.html

Thanks.
I have read it. It is helpful.