guys i am really confused about this one concept for anesthetics..there was a question on uworld asking if an anesthetic had a high arteriovenous gradient then how would it affect the anesthetic..
the answer was it will cause it to have a slower onset of action...
now the explanation confused me..it said that AV gradient signifies tissue solubility so when the anesthetic has a high solubility a large amount of anesthetic is taken from the arterial side and less is given off at the venous side..which i assume means a high AV gradient and also the drug having a low onset of action..Now if the tissue is getting more drug on the arterial side isn't that supposed to be good? so how will the onset of action be slow?
can someone plz explain this to me..i tried reading it up from lippincott too but I didn't understand that clearly either
the answer was it will cause it to have a slower onset of action...
now the explanation confused me..it said that AV gradient signifies tissue solubility so when the anesthetic has a high solubility a large amount of anesthetic is taken from the arterial side and less is given off at the venous side..which i assume means a high AV gradient and also the drug having a low onset of action..Now if the tissue is getting more drug on the arterial side isn't that supposed to be good? so how will the onset of action be slow?
can someone plz explain this to me..i tried reading it up from lippincott too but I didn't understand that clearly either