[Sabio]

Family pedigree questions are common in USMLE and they frequently make us scratch our heads!

Here's a flow chart that may help


click image to enlarge

If you have nice challenging family pedigree questions post your replies to this thread

 

[khanar]

Nice flowchart!

 

[khanar]

Can you believe that I've got a multifactorial disease pedigree!
It was hypertension
I don't think your rules work in such cases

 

[indian]

Just wanted to share something with you

I have seen a question showing a typical autosomal recessive inheritance and then the correct answer was down syndrome !!!

 

[Sabio]

Just wanted to share something with you

I have seen a question showing a typical autosomal recessive inheritance and then the correct answer was down syndrome !!!

Woe
It has been said that Down syndrome due to Roberstonian translocation may follow an inheritance pattern similar to autosomal recessive.

This is really a tricky question, but they must hint you about Down in some other ways other than the family pedigree otherwise no genius can answer it.

 

[bebix]

genetic pedigree & to determine the most likely mode of inheritance

Pretty nice video teaching how to determine the most likely mode of inheritance: