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Antidepressants Mechanism of Action - FA 2010

9567 Views 4 Replies 4 Participants Last post by  heights, 
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Can someone please explain this?


What I think is happening:

Tricyclics & SSRI's are preventing the re uptake of NE & 5-HT, therefore there is more available extracellularly for action in the post synapse.

The MAO Inhibitors are preventing MAO from metabolizing both NE & 5-HT so more can be use in the synapse.

So all the actions of the drugs are synergistic? :rolleyes:

This is from FA 2010, Psychiatry Chapter, Page 452
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Hope2Pass said:
This image just shows the actions of the three different types of Drugs - SSRI's, MAOI's and TCA's. They have just showed one image instead of showing three different ones because the site of action is the same; i.e the synapse junction.

Correct me *someone* if im wrong but i think in innovative therapy for patients who are resistant to normal therapy, a physician could combine the drugs but only to a certain extent because of hyperthermic and hypertensive crisis that can rise.

Hope this helps and waiting for more replies because I would like to see an answer to this as well!
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The hypertensive crisis occurs with MAO Inhibitors regardless, its cause of the ''cheese reaction'', which is why MAOI's are 3rd line drugs...
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