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Patient with Marfan syndrome is at risk for Aortic dissection.
Marfan syndrome has mutation at fibrillin so I'll go with fibrillin

INTRAMURAL AORTIC HEMATOMA AND AORTIC DISSECTION
Definition
An intramural aortic hematoma occurs when bleeding from the vasa vasorum causes a hematoma within the aortic media. Aortic dissection occurs when the media of the blood vessel is cleaved longitudinally to form a false lumen that communicates with the true lumen.
The location of an intramural aortic hematoma or dissection may be described according to one of several classification systems .
Two thirds of aortic dissections are type A (proximal) and the other third are type B (distal). The classification schemes all serve the same purpose, which is to distinguish dissections that involve the ascending aorta from dissections that do not. Involvement of the ascending aorta carries a high risk for early rupture and death from cardiac tamponade, so the prognosis and management differ according to the extent of aortic involvement. Hematomas and dissections are also classified according to their duration: less than 2 weeks is considered acute, whereas 2 weeks or more is considered chronic.

Head Eye Human body Jaw Organism
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The peak incidence of aortic dissection in patients without Marfan syndrome is in their 60s and 70s, and men are affected twice as often as women. A history of hypertension is present in most cases, whereas a bicuspid aortic valve or known preexisting thoracic aortic aneurysm is less common. Rarely, aortic dissection may occur in a young woman during the peripartum period. Iatrogenic trauma from intra-aortic catheterization procedures or cardiac surgery may also cause aortic dissection.
Pathobiology
Disease of the aortic media, with degeneration of the medial collagen and elastin, is the most common predisposing factor for aortic dissection. Patients with Marfan syndrome have classic cystic medial degeneration and are at particularly high risk for aortic dissection at a relatively young age. Aortic dissection classically begins either with a tear in the aortic intima, thereby exposing the diseased medial layer to the systemic pressure of intraluminal blood, or with an intramural hematoma caused by bleeding in the vasa vasorum of the arterial wall. This hematoma may propagate longitudinally along a variable length of the aorta. If the intimal layer remains intact, the hematoma does not communicate with the aortic lumen, but if it does, it will become no different than a dissection that began with an intimal tear. The result will be cleavage of the media into two layers longitudinally, thereby producing a blood-filled false lumen within the aortic wall. This false lumen propagates distally (or sometimes retrogradely) a variable distance along the aorta from the site of the intimal tear.
MARFAN SYNDROME
Definition Marfan syndrome is an autosomal dominant, pleiotropic disorder caused by defects in the principal component of the extracellular microfibril, the large glycoprotein fibrillin-1. The disease manifestations occur in multiple systems, especially the eye, skeleton, heart, aorta, lung, and integument. Notable features include dislocation of the ocular lens, tall stature with particularly long limbs and digits, deformity of the thoracic cage from pectus carinatum or excavatum with abnormal curvature of the spine, mitral and tricuspid valve prolapse, dilation of the sinuses of Valsalva and predisposition to aortic dissection, spontaneous pneumothorax, abnormal skin stretch marks, hernias, and dural ectasia. If untreated, patients often die before 30 or 40 years of age from aortic dissection or congestive heart failure.
 
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