OK, let's now talk about Mercaptopurine and Allopurinol.
Is it exactly the same story as Azathiprine and Allopurinol or is there something else playing here?
What makes you believe something else is going on here? The job of xanthine oxidase is to add oxygen subgroups in the purine backbone (hypoxanthine<-->xanthine & xanthine<-->uric acid), regardless of what extras are attached to this backbone.
Because Allopurinol and 6MP also blocks PRPP Amidotransferase which is the rate limiting enzyme in purine synthesis. However, in order for them to do that they have to be converted to their nucleotide versions by the action of HPRT.
Add to this that Allopurinol blocks Xanthine Oxidase while 6MP is deactivated by Xanthine Oxidase.
So there's kind of complex interrelations that bugging my head
@ ath.pantelis
You are the smarted USMLEr I have ever met on the Internet!
God bless you
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