USMLE Forums banner
1 - 4 of 4 Posts

·
Registered
Joined
·
475 Posts
Discussion Starter · #1 ·
Hi Guys!

What's your understanding of how B blockers facilitate hypoglycemia and hyperkalemia?

Thanks in advance
 

·
Registered
Joined
·
220 Posts
Potassium has many ways of entering or exiting the cells.

One factor that blocks potassium entry is B blockers whilst b-agonists aid the entry of K into the cell. That's why one of the treatment modalities of hyperkalemia is b-agonists.

Now, as far as hypoglycemia is concerned:

The sympathetic system employs many insulin counterregulatory hormones such as the catecholamines which promote glycogenolysis and glyconeogenesis when glucose levels are low. This effect is largely mediated through b-agonist effects of epinephrine and norepinephrine on the a-cells of the pancreas which secrete glucagon as well as the liver. If you block the b-receptors you hamper the ability of the body to raise the levels of glucose when deemed necessary, thus, exacerbating any hypoglycemic state. This is particularly important for diabetic patients who take insulin. If they take b-blockers they are prone to hypoglycemic episodes, and on top of that they lack most of the hypoglycemic symptomatology i.e tremors, diaphoresis, which are signs of sympatheticotonia, making the pt unable to know that he currently suffers from hypoglycemia.

Hope I have covered you!:)
 

·
Registered
Joined
·
475 Posts
Discussion Starter · #3 ·
useful explanation-read this!

Yes. Very helpful. Thanks tkourkou

Potassium has many ways of entering or exiting the cells.

One factor that blocks potassium entry is B blockers whilst b-agonists aid the entry of K into the cell. That's why one of the treatment modalities of hyperkalemia is b-agonists.

Now, as far as hypoglycemia is concerned:

The sympathetic system employs many insulin counterregulatory hormones such as the catecholamines which promote glycogenolysis and glyconeogenesis when glucose levels are low. This effect is largely mediated through b-agonist effects of epinephrine and norepinephrine on the a-cells of the pancreas which secrete glucagon as well as the liver. If you block the b-receptors you hamper the ability of the body to raise the levels of glucose when deemed necessary, thus, exacerbating any hypoglycemic state. This is particularly important for diabetic patients who take insulin. If they take b-blockers they are prone to hypoglycemic episodes, and on top of that they lack most of the hypoglycemic symptomatology i.e tremors, diaphoresis, which are signs of sympatheticotonia, making the pt unable to know that he currently suffers from hypoglycemia.

Hope I have covered you!:)
 

·
Registered
Joined
·
0 Posts
The activity of the animal beings has become acutely active everywhere on this earth. Bodies do not get time to booty a blow for a while. With the accretion use of altered gadgets of Gps Jammer, the possibilities of accepting the aboriginal of blow accept absolutely finished. The adaptable phones or the corpuscle phones are some of these accessories that accumulate the bodies consistently in blow with the alfresco world. The adaptable building are additionally accessible about everywhere these canicule and due to this the accessibility of the Cell Phone Jammer has become alike added quick and authentic. Today, you cannot break out of ability of these adaptable building as their signals can bolt your about anywhere. The bearings of bodies who accord to altered business professions has become actual analytical of wifi jammer as their authorities bolt them anywhere any moment.
 
1 - 4 of 4 Posts
Top