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Discussion Starter #1
A 50-year-old man is evaluated by a physician after developing recurrent bouts of bilateral pneumonitis with nodular and cavitary pulmonary infiltrates. The man also has a long history of sinusitis. Nasal biopsy demonstrates a necrotizing vasculitis with granulomas. This man is also particularly vulnerable to serious disease of which of the following organs?

(A) Heart
(B) Kidneys
(C) Liver
(D) Testes​
(E) Thyroid
 

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Discussion Starter #5
Wegener granulomatosis is a necrotizing vasculitis that affects small arteries and veins. This disease develops over a period of months and classically involves the nose, sinuses, lungs, and kidneys.Patients usually present with upper or lower respiratory symptoms such as chronic sinusitis, otitis,hemoptysis, nasopharyngeal ulcerations, and bilateral pneumonitis with nodular and cavitary pulmonary infiltrates.
2nd most common organ affected is kidney...IgG and complements are found in renal biopsies,but the most specific laboratory finding is the presence of circulating c-ANCA.:)

 
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