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A 55-year old woman undergoes surgery for a stage II invasive ductal carcinoma. The mass is removed, with the specimen showing negative margins and no lymph node involvement. To determine treatment options, immunohistochemical studies are performed to evaluate expression of receptors for estrogen, progesterone, and HER2-type EGF. Which of the following markers will most likely show immunoreactivity that is limited to the nucleus?

A. Estrogen and HER2 receptors
B. Estrogen and progesterone receptors
C. Estrogen, HER2, and progesterone receptors
D. Estrogen receptor only
E. HER2 receptor only
F. Progesterone receptor only
 

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A 55-year old woman undergoes surgery for a stage II invasive ductal carcinoma. The mass is removed, with the specimen showing negative margins and no lymph node involvement. To determine treatment options, immunohistochemical studies are performed to evaluate expression of receptors for estrogen, progesterone, and HER2-type EGF. Which of the following markers will most likely show immunoreactivity that is limited to the nucleus?

A. Estrogen and HER2 receptors
B. Estrogen and progesterone receptors
C. Estrogen, HER2, and progesterone receptors
D. Estrogen receptor only
E. HER2 receptor only
F. Progesterone receptor only
can anyone tell me what does immunoreactivity limited to the nucleus mean?
 
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