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A pharmacy fellow is trying to determine what the plasma concentration of an experimental antiarrhythmic agent (Drug X) will be at steady-state. A continuous intravenous infusion of the agent began 6 hours earlier at a rate of 3 mg/min. Drug X has a half-life of 3 hours, a volume of distribution of 120 L, and a clearance of 0.6 L/min. If the rate of infusion remains constant, what will the plasma concentration be at steady-state?

A. 0.005 mg/L
B. 0.4 mg/L
C. 2.0 mg/L
D. 5.0 mg/L
E. 40.0 mg/L
F. 200.0 mg/L
 

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steady state concentration

I have a more or less equal problem.

I want to calculate the Css with only know the urine concentration (0,5µg/l) and the half life time (60days).

It is a toxin that everybody takes up during the day by inhalation. So the Problem is that everybody takes up a different dose.

Has somebody any idea?
 
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