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The classical USMLE question describing a case of Chronic Granulomatous Disease and then asking you what other infection is the patient liable to get.

Of course you should be thinking of all of the catalase positive microorganisms.

Here's a mnemonic

SPACE

  • Staphylococci (important not confuse it with streptococci)
  • Pseudomonas aeroginosa
  • Aspergillus fumigatus
  • Candida
  • Enterobacteriaceae (specially Klebsiella and Serratia both of which can cause pneumonia and UTI)
Worth to remember that none of the anaerobes are Catalase positive

Also some others are Catalase positive

  • Nisseria (Gonorrhea & Meningitidis)
  • Vibrio
  • Nocardia
  • Campylobacter & Helicobacter
  • Gardnerella vaginalis
  • Pseudomonas cepacia
  • Mycobacterium Tebeculosis also produce a heat sensitive catalase ( active only in body temperature ) so it become catalase negative at 68.0 "F
 

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CGD is deficiency of NADPH oxidase. As a result the body is not able to protect itself against infections such as those caused by catalase+ organisms (staphylococci, pseudomonas, aspergillus, candida, enterobacters = SPACE)
 

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No HuBBLe SPACE CaMP

This has some missing information

New Mnemonic: No HuBBLe SPACE CaMP

Nocardia
o

Helicobacter pylori
u
Brucella
Burkholderia cepacia
Listeria/Legionella pneumophila
e

Staphylococci (aureus, epidermidis, saprophyticus)
Pseudomona
Aspergillus
Candida
Enterobacteriaceae

Corynebacterium
a
Mycobacterium tuberculosis
Pastereulla Multocida

with CAMP in itself a play for Campylobacter jejuni.

While Vibrio and Neisseria do produce catalase I dispute gardnerella vaginalis as being catalase negative, check sources.
 
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